GrippeEspagneV1, Main, Exploration, bibRecord, 000022

Prognostic value of pro-adrenomedullin and NT-proBNP in patients referred from the emergency department with influenza syndrome.

Identifieur interne : 000022 ( Main/Exploration ); précédent : 000021; suivant : 000023

Prognostic value of pro-adrenomedullin and NT-proBNP in patients referred from the emergency department with influenza syndrome.

Auteurs : Salvador Valero Cifuentes [Espagne] ; Eva García Villalba [Espagne] ; Antonia Alcaraz García [Espagne] ; María José Alcaraz García [Espagne] ; Ángeles Mu Oz Pérez [Espagne] ; Pascual Pi Era Salmer N [Espagne] ; Enrique Bernal Morell [Espagne]

Source :

Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias [ 2386-5857 ] ; 2019.

RBID : pubmed:31210450

Descripteurs français

KwdFr :
- Adrénomédulline (sang), Adulte (MeSH), Adulte d'âge moyen (MeSH), Aire sous la courbe (MeSH), Durée du séjour (MeSH), Espagne (épidémiologie), Facteurs âges (MeSH), Femelle (MeSH), Fragments peptidiques (sang), Grippe humaine (mortalité), Grippe humaine (sang), Humains (MeSH), Marqueurs biologiques (sang), Mortalité hospitalière (MeSH), Mâle (MeSH), Odds ratio (MeSH), Peptide natriurétique cérébral (sang), Pronostic (MeSH), Protéine C-réactive (analyse), Sujet âgé (MeSH), Études prospectives (MeSH).
MESH :
- analyse : Protéine C-réactive.
- mortalité : Grippe humaine.
- sang : Adrénomédulline, Fragments peptidiques, Grippe humaine, Marqueurs biologiques, Peptide natriurétique cérébral.
- épidémiologie : Espagne.
- Adulte, Adulte d'âge moyen, Aire sous la courbe, Durée du séjour, Facteurs âges, Femelle, Humains, Mortalité hospitalière, Mâle, Odds ratio, Pronostic, Sujet âgé, Études prospectives.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adrenomedullin (blood), Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Area Under Curve (MeSH), Biomarkers (blood), C-Reactive Protein (analysis), Female (MeSH), Hospital Mortality (MeSH), Humans (MeSH), Influenza, Human (blood), Influenza, Human (mortality), Length of Stay (MeSH), Male (MeSH), Middle Aged (MeSH), Natriuretic Peptide, Brain (blood), Odds Ratio (MeSH), Peptide Fragments (blood), Prognosis (MeSH), Prospective Studies (MeSH), Spain (epidemiology).
MESH :
- chemical , analysis : C-Reactive Protein.
- chemical , blood : Adrenomedullin, Biomarkers, Natriuretic Peptide, Brain, Peptide Fragments.
- geographic , epidemiology : Spain.
- blood : Influenza, Human.
- mortality : Influenza, Human.
- Adult, Age Factors, Aged, Area Under Curve, Female, Hospital Mortality, Humans, Length of Stay, Male, Middle Aged, Odds Ratio, Prognosis, Prospective Studies.

Abstract

OBJECTIVES

To assess the prognostic value of procalcitonin (PTC), C-reactive protein (CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and mid-regional pro-adrenomedullin (MR-proADM) in patients with influenza syndrome.

MATERIAL AND METHODS

Prospective study in patients admitted from the emergency department with influenza syndrome. Biomarker concentrations were measured in the first 24 h after admission and a test for influenza. The results were analyzed for ability to predict a hospital stay longer than 7 days, intensive care unit admission, or in-hospital death.

RESULTS

Ninety-eight patients were included; the prognosis of 44 (44.9%) was classified as poor. The areas under the receiving operator characteristic curve were 0.68 (95% CI, 0.56-0.80) for NT-proBNP, 0.73 (95% CI, 0.62-0.84) for MR-proADM, and nonsignificant for PCT and CRP. The following variables were independently associated with a poor prognosis: pneumonia (OR, 7.46 [95% CI, 2.08-26.73]; P=.002), heart failure (OR, 5.16 [95% CI, 1.35-19.74]; P=.016), and NT-proBNP > 580 pg/mL (OR, 4.68 [95% CI, 1.53-14.26]; P=.006). In the 53 patients with confirmed A(H1N1) influenza, only NT-proBNP was an independent predictor of prognosis (adjusted OR, 5.75 [95% CI, 1.46- 22.61]; P=.012).

CONCLUSION

NT-proBNP and MR-proADM were the only biomarkers with prognostic value. Only NT-proBNP was a useful predictor in patients with confirmed influenza.

PubMed: 31210450

Affiliations:

Espagne

Links toward previous steps (curation, corpus...)

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to stream Main, to step Curation: 000013

Le document en format XML

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<author><name sortKey="Alcaraz Garcia, Maria Jose" sort="Alcaraz Garcia, Maria Jose" uniqKey="Alcaraz Garcia M" first="María José" last="Alcaraz García">María José Alcaraz García</name>
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<author><name sortKey="Bernal Morell, Enrique" sort="Bernal Morell, Enrique" uniqKey="Bernal Morell E" first="Enrique" last="Bernal Morell">Enrique Bernal Morell</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenomedullin (blood)</term>
<term>Adult (MeSH)</term>
<term>Age Factors (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Area Under Curve (MeSH)</term>
<term>Biomarkers (blood)</term>
<term>C-Reactive Protein (analysis)</term>
<term>Female (MeSH)</term>
<term>Hospital Mortality (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza, Human (blood)</term>
<term>Influenza, Human (mortality)</term>
<term>Length of Stay (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Natriuretic Peptide, Brain (blood)</term>
<term>Odds Ratio (MeSH)</term>
<term>Peptide Fragments (blood)</term>
<term>Prognosis (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Spain (epidemiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adrénomédulline (sang)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Aire sous la courbe (MeSH)</term>
<term>Durée du séjour (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Facteurs âges (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Fragments peptidiques (sang)</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (sang)</term>
<term>Humains (MeSH)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Mortalité hospitalière (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Odds ratio (MeSH)</term>
<term>Peptide natriurétique cérébral (sang)</term>
<term>Pronostic (MeSH)</term>
<term>Protéine C-réactive (analyse)</term>
<term>Sujet âgé (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>C-Reactive Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenomedullin</term>
<term>Biomarkers</term>
<term>Natriuretic Peptide, Brain</term>
<term>Peptide Fragments</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéine C-réactive</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Adrénomédulline</term>
<term>Fragments peptidiques</term>
<term>Grippe humaine</term>
<term>Marqueurs biologiques</term>
<term>Peptide natriurétique cérébral</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Area Under Curve</term>
<term>Female</term>
<term>Hospital Mortality</term>
<term>Humans</term>
<term>Length of Stay</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Aire sous la courbe</term>
<term>Durée du séjour</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mortalité hospitalière</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Pronostic</term>
<term>Sujet âgé</term>
<term>Études prospectives</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>To assess the prognostic value of procalcitonin (PTC), C-reactive protein (CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and mid-regional pro-adrenomedullin (MR-proADM) in patients with influenza syndrome.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MATERIAL AND METHODS</b>
</p>
<p>Prospective study in patients admitted from the emergency department with influenza syndrome. Biomarker concentrations were measured in the first 24 h after admission and a test for influenza. The results were analyzed for ability to predict a hospital stay longer than 7 days, intensive care unit admission, or in-hospital death.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Ninety-eight patients were included; the prognosis of 44 (44.9%) was classified as poor. The areas under the receiving operator characteristic curve were 0.68 (95% CI, 0.56-0.80) for NT-proBNP, 0.73 (95% CI, 0.62-0.84) for MR-proADM, and nonsignificant for PCT and CRP. The following variables were independently associated with a poor prognosis: pneumonia (OR, 7.46 [95% CI, 2.08-26.73]; P=.002), heart failure (OR, 5.16 [95% CI, 1.35-19.74]; P=.016), and NT-proBNP > 580 pg/mL (OR, 4.68 [95% CI, 1.53-14.26]; P=.006). In the 53 patients with confirmed A(H1N1) influenza, only NT-proBNP was an independent predictor of prognosis (adjusted OR, 5.75 [95% CI, 1.46- 22.61]; P=.012).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>NT-proBNP and MR-proADM were the only biomarkers with prognostic value. Only NT-proBNP was a useful predictor in patients with confirmed influenza.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31210450</PMID>
<DateCompleted><Year>2020</Year>
<Month>05</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>05</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2386-5857</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>31</Volume>
<Issue>3</Issue>
<PubDate><Year>2019</Year>
<Month>Jun</Month>
</PubDate>
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<Title>Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias</Title>
<ISOAbbreviation>Emergencias</ISOAbbreviation>
</Journal>
<ArticleTitle>Prognostic value of pro-adrenomedullin and NT-proBNP in patients referred from the emergency department with influenza syndrome.</ArticleTitle>
<Pagination><MedlinePgn>180-184</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVES">To assess the prognostic value of procalcitonin (PTC), C-reactive protein (CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and mid-regional pro-adrenomedullin (MR-proADM) in patients with influenza syndrome.</AbstractText>
<AbstractText Label="MATERIAL AND METHODS">Prospective study in patients admitted from the emergency department with influenza syndrome. Biomarker concentrations were measured in the first 24 h after admission and a test for influenza. The results were analyzed for ability to predict a hospital stay longer than 7 days, intensive care unit admission, or in-hospital death.</AbstractText>
<AbstractText Label="RESULTS">Ninety-eight patients were included; the prognosis of 44 (44.9%) was classified as poor. The areas under the receiving operator characteristic curve were 0.68 (95% CI, 0.56-0.80) for NT-proBNP, 0.73 (95% CI, 0.62-0.84) for MR-proADM, and nonsignificant for PCT and CRP. The following variables were independently associated with a poor prognosis: pneumonia (OR, 7.46 [95% CI, 2.08-26.73]; P=.002), heart failure (OR, 5.16 [95% CI, 1.35-19.74]; P=.016), and NT-proBNP > 580 pg/mL (OR, 4.68 [95% CI, 1.53-14.26]; P=.006). In the 53 patients with confirmed A(H1N1) influenza, only NT-proBNP was an independent predictor of prognosis (adjusted OR, 5.75 [95% CI, 1.46- 22.61]; P=.012).</AbstractText>
<AbstractText Label="CONCLUSION">NT-proBNP and MR-proADM were the only biomarkers with prognostic value. Only NT-proBNP was a useful predictor in patients with confirmed influenza.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Valero Cifuentes</LastName>
<ForeName>Salvador</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Hospital General Universitario Reina Sofía, Murcia, España.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García Villalba</LastName>
<ForeName>Eva</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Hospital General Universitario Reina Sofía, Murcia, España.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alcaraz García</LastName>
<ForeName>Antonia</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Hospital General Universitario Reina Sofía, Murcia, España.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alcaraz García</LastName>
<ForeName>María José</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Hospital General Universitario Reina Sofía, Murcia, España.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muñoz Pérez</LastName>
<ForeName>Ángeles</ForeName>
<Initials>Á</Initials>
<AffiliationInfo><Affiliation>Hospital General Universitario Reina Sofía, Murcia, España.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Piñera Salmerón</LastName>
<ForeName>Pascual</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Hospital General Universitario Reina Sofía, Murcia, España.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bernal Morell</LastName>
<ForeName>Enrique</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Hospital General Universitario Reina Sofía, Murcia, España.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<Language>spa</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
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<VernacularTitle>Valor pronóstico de la proadrenomedulina y el NT-proBNP en los pacientes procedentes de urgencias con síndrome gripal.</VernacularTitle>
</Article>
<MedlineJournalInfo><Country>Spain</Country>
<MedlineTA>Emergencias</MedlineTA>
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<ISSNLinking>1137-6821</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010446">Peptide Fragments</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C109794">pro-brain natriuretic peptide (1-76)</NameOfSubstance>
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<Chemical><RegistryNumber>114471-18-0</RegistryNumber>
<NameOfSubstance UI="D020097">Natriuretic Peptide, Brain</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>148498-78-6</RegistryNumber>
<NameOfSubstance UI="D053607">Adrenomedullin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9007-41-4</RegistryNumber>
<NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D053607" MajorTopicYN="N">Adrenomedullin</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019540" MajorTopicYN="N">Area Under Curve</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020097" MajorTopicYN="N">Natriuretic Peptide, Brain</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010446" MajorTopicYN="N">Peptide Fragments</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherAbstract Type="Publisher" Language="spa"><AbstractText Label="OBJETIVO">Analizar el valor pronóstico de la procalcitonina (PCT), la proteína C reactiva (PCR), el NT-proBNP y la región medial de la proadrenomedulina (MR-proADM) en pacientes hospitalizados con síndrome gripal.</AbstractText>
<AbstractText Label="METODO">Estudio prospectivo realizado en pacientes hospitalizados desde urgencias por síndrome gripal. Se analizaron las concentraciones de biomarcadores en las primeras 24 h de ingreso y el test de gripe y se analizó su capacidad predictiva de mal pronóstico: estancia superior a 7 días, ingreso en unidad de cuidados intensivos o fallecimiento intrahospitalario.</AbstractText>
<AbstractText Label="RESULTADOS">Se incluyeron 98 pacientes, 44 (44,9%) de ellos con mal pronóstico. Las áreas bajo la curva COR para mal pronóstico fueron de 0,68 (IC 95% 0,56-0,80) para NT-proBNP y de 0,73 (IC 95% 0,62-0,84) para la MRproADM, y no significativas para PCT y PCR. Las variables asociadas independientemente con mal pronóstico fueron: neumonía (OR 7,46 [IC 95% 2,08-26,73]; p = 0,002), insuficiencia cardiaca (OR 5,16 [IC 95% 1,35-19,74]; p = 0,016) y NT-proBNP > 580 pg/ml (OR 4,68 [IC 95% 1,53-14,26]; p = 0,006). En los 53 pacientes con gripe A(H1N1) confirmada, solo el NT-proBNP tuvo un valor pronóstico independiente (OR ajustado 5,75 [IC 95% 1,46-22,61]; p = 0,012).</AbstractText>
<AbstractText Label="CONCLUSIONES">En pacientes con síndrome gripal, el NT-proBNP y la MR-proADM fueron los únicos biomarcadores con valor pronóstico, y solo el primero de ellos mantuvo esta asociación en pacientes con gripe confirmada.</AbstractText>
</OtherAbstract>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">  reactiva</Keyword>
<Keyword MajorTopicYN="Y"> Biomarcadores</Keyword>
<Keyword MajorTopicYN="Y"> Influenza virus A(H1N1)pmd09</Keyword>
<Keyword MajorTopicYN="Y"> NT-proBNP</Keyword>
<Keyword MajorTopicYN="Y"> Pandemics, influenza</Keyword>
<Keyword MajorTopicYN="Y"> Proadrenomedullin</Keyword>
<Keyword MajorTopicYN="Y"> Procalcitonin</Keyword>
<Keyword MajorTopicYN="Y"> Procalcitonina</Keyword>
<Keyword MajorTopicYN="Y"> Proteína C</Keyword>
<Keyword MajorTopicYN="Y">Biological markers</Keyword>
<Keyword MajorTopicYN="Y">C-reactive protein</Keyword>
<Keyword MajorTopicYN="Y">Gripe pandémica</Keyword>
<Keyword MajorTopicYN="Y">NT-proBNP</Keyword>
<Keyword MajorTopicYN="Y">Proadrenomedulina</Keyword>
<Keyword MajorTopicYN="Y">Prognosis</Keyword>
<Keyword MajorTopicYN="Y">Pronóstico</Keyword>
<Keyword MajorTopicYN="Y">Virus de la gripe A(H1N1)pmd09</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>6</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>6</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>5</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31210450</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Valero Cifuentes, Salvador" sort="Valero Cifuentes, Salvador" uniqKey="Valero Cifuentes S" first="Salvador" last="Valero Cifuentes">Salvador Valero Cifuentes</name>
</noRegion>
<name sortKey="Alcaraz Garcia, Antonia" sort="Alcaraz Garcia, Antonia" uniqKey="Alcaraz Garcia A" first="Antonia" last="Alcaraz García">Antonia Alcaraz García</name>
<name sortKey="Alcaraz Garcia, Maria Jose" sort="Alcaraz Garcia, Maria Jose" uniqKey="Alcaraz Garcia M" first="María José" last="Alcaraz García">María José Alcaraz García</name>
<name sortKey="Bernal Morell, Enrique" sort="Bernal Morell, Enrique" uniqKey="Bernal Morell E" first="Enrique" last="Bernal Morell">Enrique Bernal Morell</name>
<name sortKey="Garcia Villalba, Eva" sort="Garcia Villalba, Eva" uniqKey="Garcia Villalba E" first="Eva" last="García Villalba">Eva García Villalba</name>
<name sortKey="Mu Oz Perez, Angeles" sort="Mu Oz Perez, Angeles" uniqKey="Mu Oz Perez A" first="Ángeles" last="Mu Oz Pérez">Ángeles Mu Oz Pérez</name>
<name sortKey="Pi Era Salmer N, Pascual" sort="Pi Era Salmer N, Pascual" uniqKey="Pi Era Salmer N P" first="Pascual" last="Pi Era Salmer N">Pascual Pi Era Salmer N</name>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur la grippe en Espagne
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Prognostic value of pro-adrenomedullin and NT-proBNP in patients referred from the emergency department with influenza syndrome.

Prognostic value of pro-adrenomedullin and NT-proBNP in patients referred from the emergency department with influenza syndrome.

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